Horford went down with a knee injury in the first quarter of Sunday night's game in Detroit, but returned and finished with 18 points, 9 rebounds, and 6 assists.
Kyrie, meanwhile, was held scoreless in the fourth quarter for the first time this season.
The Bulls are one of the worst teams in the NBA right now, so the C's may be able to afford to sit Kyrie and Al, but it's something to look out for heading home to Boston for matchups with the Jazz and Nuggets.
Follow Topher Lane on Twitter, @Topher_L. Photo credit: USA TODAY Sports